Conduct COVID-19 vaccine effectiveness analyses
Client
Goal
To generate COVID-19 vaccine effectiveness (VE) estimates using data from four studies conducted in Egypt, Iran, Jordan, and Pakistan, as well as technical support to the countries’ research teams in data analysis.
Scope
From October to December 2023, MMGH provided technical support to the four countries and to the WHO-EMRO technical team coordinating
these studies. The support included a) inspection of data for quality issues, b) written and verbal feedback on documents prepared by study PIs (study protocols, reports and presentations), and c)
preparation of report and presentation templates. Study data were obtained from the Research Electronic Data Capture platform (REDCap). The data were analysed to generate VE estimates per study
and, as possible and appropriate, pooled by study design.
Result
The four studies with wide confidence intervals demonstrate the increasing challenge of obtaining reliable VE estimates late during the COVID-19 pandemic in the Omicron dominant period. The challenges encountered underscore the importance of regional collaboration and flexibility to adapt to context-specific needs while minimizing deviations from standardized protocols. The WHO support enhanced the national capacity for VE studies during future pandemics and large disease outbreaks.
Focus Area
Evaluation